Epithalon 10mg 5 Vials

Epithalon – 10mg (5 Vials)

History – What is Epithalon?

Epithalon (also known as Epitalon or Epithalone) is the synthetic version of the polypeptide Epithalamin which is naturally produced in the pineal gland. It was synthesized by Vladimir Khavinson, a Russian professor and gerontologist, whose research focused on the development of peptide preparations used to restore function in various organs in order to prevent and reverse the aging process. He is currently the Director of the Saint Petersburg Institute of Bioregulation and Gerontology.

Epithalon is considered the “fountain of youth” peptide. It is a tetra-peptide, which means that it is composed of four amino acid chains. The peptide is used to regulate the cell cycle during telomerase activity. Telomerase, also called telomere terminal transferase, is an enzyme made of protein and RNA subunits that elongates chromosomes. When telomerase activity is not present (when we age), our cells age. Our telomeres get shorter and begin to die off. If telomerase is activated in our cells, our telomeres lengthen, the cell continues to grow and divide, delaying the aging process. (UT Southwestern Medical Lab)

Epithalon Uses

Epithalon is a synthetic peptide made of four amino acids (alanine, glutamic acid, aspartic acid, and glycine), that is based on a natural peptide called epithalamin extracted from the pineal gland. It was synthesized by Vladimir Khavinson, a Russian professor and gerontologist, whose research focused on the development of peptide preparations used to restore function in various organs in order to prevent and reverse the aging process. He is currently the Director of the Saint Petersburg Institute of Bioregulation and Gerontology.

Epithalon Benefits

As a result of Epithalon’s effect on telomerase production, the benefits are unique and far-reaching and include:

• Increases lifespan by lengthening telomeres in human cells|
• Promotes deeper sleep
• Delays and prevents of age-related diseases such as cancer, heart disease, and dementia
• Acts as an antioxidant by reducing lipid oxidation and ROS (Reactive oxygen species) along with normalizing T cell function
• Improves skin health and appearance
• Heals injured and deteriorating muscle cells
• Restores and normalizes melatonin levels in those who have lost some pineal function due to aging
• Can increase resistance to emotional stress

Epithalon Peptide (Telomerase Activating Peptide)

Epithalon is a synthetic peptide, telomerase activator, and putative anti-aging drug developed by the St. Petersburg Institute of Bioregulation and Gerontology, which was identified as the putative active component of a bovine pineal gland extract known as epithalamin.

Most studies on epithalon and epithalamin have been conducted by the St. Petersburg Institute of Bioregulation and Gerontology, primarily overseen by Vladimir Khavinson, in Russia.

In addition, scientific studies have also shown other great possible benefits of Epithalon as prevention of cancer and age-related diseases, restoration and normalization of melatonin levels, promotion of deeper sleep and strong anti-oxidant properties. Epitalon is patented by its discoverer Professor Khavinson and was approved for general use in Russia in 1990 and has since been used in gerontology. Many scientific studies and clinical trials of Epitalon have been conducted in both animals and humans, and no adverse side effects have ever been reported to date.

Epithalon is a tetrapeptide with the amino acid sequence Ala–Glu–Asp–Gly and the molecular formula C₁₄H₂₂N₄O₉.

Epithalon Animal Studies In Vivo

An in vivo study in aging mice found that epithalon treatment significantly reduced the incidence of chromosomal aberrations, both for wild-type mice and for mice characterized by an accelerated aging phenotype, which is consistent with increases in telomere length.

Another study in aging rats found that the molecule increased the activities of the antioxidant enzymes superoxide dismutase, glutathione peroxidase, and glutathione-S-transferase.^[3]

Epithalon reduced the number of spontaneous tumors and the number of metastases in mice that did develop spontaneous tumors in an experiment on one-year-old female C3H/He mice, and is speculated to have oncostatic and anti-metastatic properties.

In a study of chickens subjected to neonatal hypophysectomy and subsequent maturation, the molecule promoted the recovery of the morphological structures of the thymus, as well as the structure and function of the thyroid gland.

Epithalon appears to increase the proliferation of lymphocytes in the thymus, putatively increasing production of interferon gamma by T-cells.

Another study in aging rats demonstrated extension of life span for rats subjected to constant illumination or to a natural light regimen typical of northern regions.

Learn More About Epithalon

1. NCBI: https://pubmed.ncbi.nlm.nih.gov/?term=epitalon
2. ScienceDirect: https://www.sciencedirect.com/search?qs=epitalon
3. ResearchGate: https://www.researchgate.net/search?q=epitalon
4. Wiki: https://en.wikipedia.org/wiki/Epitalon

Epithalon Research

1. “Effects of Epithalon (Ala-Glu-Asp-Gly) on life span, antioxidant system, and DNA damage in Drosophila melanogaster in stress conditions.” URL: https://www.sciencedirect.com/science/article/abs/pii/S0300483X1730560X
2. “Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells and extends life span of  mice.” URL: https://pubmed.ncbi.nlm.nih.gov/17356867/
3. “Epithalon (Ala-Glu-Asp-Gly) modulates apoptosis and proliferation in the thymus and spleen under stress conditions.” URL: https://www.sciencedirect.com/science/article/abs/pii/S0024320516301575
4. “Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells and extends life span of mice.” URL: https://pubmed.ncbi.nlm.nih.gov/17356867/
5. “Epithalon-induced regulation of aging-associated genes in human diploid fibroblasts.” URL: https://pubmed.ncbi.nlm.nih.gov/26343104/
6. “Epithalon (Ala-Glu-Asp-Gly) regulates oxidative stress and inflammatory response in UV-irradiated human skin fibroblasts.” URL: https://www.sciencedirect.com/science/article/abs/pii/S0024320518300952
7. “Epithalon (Ala-Glu-Asp-Gly) improves the immune status of human blood mononuclears and prolongs the life span of mice.” URL: https://www.sciencedirect.com/science/article/abs/pii/S0024320506002809
8. “Epithalon (Ala-Glu-Asp-Gly) modulates oxidative stress and inflammatory response in liver of old rats.” URL: https://www.sciencedirect.com/science/article/abs/pii/S0024320516301290
9. “Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells and extends life span of mice.” URL: https://pubmed.ncbi.nlm.nih.gov/17356867/
10. “Epithalon regulates expression of senescence markers in human diploid fibroblasts.” URL: https://www.sciencedirect.com/science/article/abs/pii/S0300483X18304216

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Epithalon – 10mg (5 Vials) 

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